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The Gut Microbiome Connection: Advancing Systemic Health Protocols

Friday, September 26th, 2025 | Breakout Room 3

When Symptoms Persist, the Microbiome May Hold the Answers

You’ve targeted hormones, detoxified the system, and optimized nutrition, yet patients still struggle with inflammation, fatigue, and immune reactivity. It’s time to view the gut not as a digestive organ, but central regulator of systemic health and biological aging.

Gut-Track

The Hidden Driver of Systemic Dysfunction

Despite advanced protocols and solid lifestyle compliance, many patients present with persistent symptoms: autoimmune flares, brain fog, nutrient depletion, and skin issues. These aren’t isolated concerns—they’re often rooted in gut-derived inflammation, permeability, and microbial imbalance.

This session empowers you to decode these patterns using Vibrant’s advanced stool and serum markers. You’ll learn how to interpret data from the Gut Zoomer and Food Sensitivity panels to design targeted, effective protocols that restore microbial balance and resolve systemic dysfunction at its root.

Key Learning Objectives

The gut is more than a digestive organ. It’s a command center for immune regulation, metabolic balance, cognitive clarity, and inflammation control. This track will walk you through how to clinically apply microbiome insights to support whole-body health and extend patient vitality.

  • Reveal what others miss: Learn how markers like zonulin, anti-actin, and anti-LPS IgA indicate gut permeability, while calprotectin, lysozyme, and eosinophil protein X signal inflammation and immune activation. Explore food-related immune responses via IgG/IgA sensitivity panels.
  • Connect gut data to systemic aging: Trace how gut dysfunction contributes to oxidative stress and inflammation using markers such as CRP, oxidized LDL, and 8-OHdG, and how these patterns accelerate biological aging.
  • Deliver real solutions: Move beyond general GI protocols. Design phased interventions using elimination diets, biofilm disruptors, targeted antimicrobials, and precision prebiotic/probiotic strategies anchored to each patient’s unique biomarker profile.
  • Implement personalized programs: Integrate findings from the Gut Zoomer, Food Sensitivity Complete, and Healthspan Assessment Panel to build structured 8–12 week care cycles. Include micronutrient repletion where deficiencies impair gut healing and immune tolerance.

You’ll leave with test-driven protocols, clinical tools, and patient-friendly program frameworks ready to implement Monday morning.

Clinical Snapshot

When Gut Data Redefined the Plan

Patient: 38-year-old female with eczema, joint pain, and mood instability

History: Minimal response to elimination diets and general GI supplements

Findings:

  • Elevated zonulin and anti-LPS IgA
  • Positive IgG and IgA responses to gluten, egg, and dairy
  • Increased calprotectin, low butyrate-producing species
  • Low B12 and zinc on micronutrient testing

Protocol:

  • 4-week elimination and anti-inflammatory diet phase
  • 8-week antimicrobial + probiotic regimen with biofilm support
  • Nutrient repletion with targeted supplementation

Outcome: Resolution of eczema, improved mood, normalized joint mobility, and improved micronutrient status by week 12.

Traditional GI Workups vs. Precision Microbiome Medicine

Conventional GI tests focus on pathogens and basic inflammation. Precision microbiome models assess diversity, permeability, and immune signaling to drive deeper systemic change.

Focus

Protocol Design

Lab Monitoring

Patient Buy-in

Clinical Impact

Traditional GI Panel

Pathogens, basic inflammation

General GI support

Often none

Moderate

Limited

Precision Microbiome Medicine

Microbial diversity, permeability, immune cross-talk

Marker-specific, phased with biofilm strategies

Baseline + follow-up testing

High (visual report data, symptom tracking)

Systemic change through gut-immune recalibration

Who This Track Is For

Brain FogLongevity practitioners treating complex chronic illness

Frustrated-ProviderProviders with patients stuck despite clean GI panels

Revenue-ProgramClinics looking to deliver gut-based programs that scale

Gut-HealthAnyone wanting to leverage the microbiome to support cognition, immunity, and inflammation control

Make Gut Health a Cornerstone of Your Practice

Longevity patients expect comprehensive, integrative care, and the microbiome is central to that model.

This track shows you how to use microbiome data not only to resolve digestive issues but to advance systemic health, support immune tolerance, and extend healthspan.

You'll learn how to:

  • Implement test-driven protocols for dysbiosis, leaky gut, and food immune reactivity
  • Use gut data to address systemic symptoms—brain fog, autoimmunity, fatigue, and inflammation
  • Build scalable gut programs around 8–12 week models with bundled retesting for better outcomes and retention

Whether you’re supporting autoimmune patients, aging adults, or high-performance biohackers, the gut is the access point. Make it your differentiator.

Speaker Lineup

Dr. Tom OBryan DC

Dr. Tom O'Bryan DC, CCN, DABCN, CIFM

Learning Track Speaker
Dr. Dan Kalish

Dr. Dan Kalish, DC

Learning Track Speaker
Dr. Kyle Gillett

Dr. Kyle Gillett, MD

Learning Track Speaker
Dr. Sue Mitchell, MD

Dr. Sue Mitchell, MD

Learning Track Speaker
Longevity-Summit-Logo-Std

Interested in locking in your spot at The Gut Microbiome Connection: Advancing Systemic Health Protocols

Be sure to sign up for this learning track at registration when you arrive at The Vibrant Longevity Summit.