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Hormone Optimization: Elevating Lifespan and Peak Clinical Performance

Thursday, Sept. 25th and Friday, Sept. 26th 2025 | Breakout Room 2

When Symptoms Persist, Look Beyond Serum Hormones 

Energy crashes, mood instability, poor sleep, and body composition changes aren’t just signs of aging—they’re often markers of hormonal misfires at the metabolic and detoxification levels. Yet most panels stop at hormone levels, ignoring how those hormones are processed, cleared, and blocked.

This track shows you how to go deeper by using urine metabolite testing, methylation data, and toxin burden to uncover why hormonal protocols plateau and how to build more innovative, phase-based interventions.

Hormones-Track

The Overlooked Layers of Hormonal Dysfunction

Hormones are more than numbers on a serum test. They’re part of a dynamic system influenced by methylation, toxin load, adrenal function, and endocrine receptor sensitivity. This session empowers you to decode that system using Vibrant’s Hormone Zoomer, Methylation Panel, Total Tox Burden, and companion tests.

Learn how to interpret hormone metabolism pathways, assess receptor interference from toxins like BPA and phthalates, and restore balance with data-driven interventions tailored to each stage of life and performance demand.

Key Learning Objectives

Hormonal balance goes beyond replacement. It involves regulation, clearance, and how cells respond. This track focuses on building hormone protocols that not only manage symptoms but also support long-term resilience and healthy aging.

  • Reveal metabolite-driven insights: Use wet urine testing to assess diurnal cortisol rhythm, cortisol metabolites, and estrogen detox patterns like 2-OH, 4-OH, and 16-OH ratios. Evaluate COMT efficiency, 2-MeO-E1 levels, and SNPs that affect hormone clearance.
  • Detect endocrine disruptors: Understand how total toxic burden (BPA, phthalates, parabens) disrupts receptor signaling and metabolism, and learn how to test and detox patients with high toxic interference.
  • Design precision hormone protocols: Create interventions that integrate circadian alignment, adrenal recalibration, methylation support, and endocrine repair. Apply insights from MTHFR, CYP1B1, and GST genotyping to personalize support.
  • Deliver structured programs with staying power: Build 3–6-month protocols that support long-term hormone recalibration, bundle lab testing, and use before/after data to retain patients and demonstrate value.

You’ll leave with protocols, lab interpretation frameworks, and business-ready hormone programs that integrate seamlessly into your clinical offerings.

Clinical Snapshot

When Metabolites and Toxins Explained It All

Patient: 52-year-old male entrepreneur with chronic fatigue, low motivation, and muscle loss

History: Normal serum testosterone, low DHEA, previous adrenal support with minimal results

Findings:

  • Flat diurnal cortisol curve and low free cortisol metabolites (Hormone Zoomer)
  • Impaired 2-OH to 2-MeO-E1 conversion, low COMT activity
  • BPA and phthalates elevated (Total Tox Burden)
  • MTHFR C677T homozygous, low methylation capacity

Protocol:

  • Circadian realignment using light exposure and adaptogenic support
  • Methylated B-vitamin regimen to support hormone detox
  • 8-week detox protocol targeting endocrine disruptors
  • Nutrient repletion phase followed by targeted hormone precursors

Outcome: Improved energy, normalized sleep, and positive trends in hormone metabolism on 3-month retest.

Basic Hormone Panels vs. Precision Endocrine Optimization

Most hormone panels only capture serum levels, limiting the clinical picture. Precision models look at hormone metabolism, detox capacity, receptor function, and genetic factors to guide individualized care.

 

Focus

Protocol Design

 

Monitoring

Clinical Results

 

Patient Buy-in

Conventional Neurology

Serum levels only

One-size-fits-all HRT or supplements

Sporadic

Inconsistent

Low (unclear outcomes)

Precision Hormone Optimization

Metabolism, detox, receptor function

Metabolite-specific, toxin-aware, SNP-informed

Pre/post cycles, retesting included

Measurable change with clear patient buy-in

High (objective data + visible progress)

Who This Track Is For

Brain FogProviders treating hormone-resistant fatigue, burnout, or weight gain

MenopauseClinicians serving perimenopausal or high-performance populations

Revenue-ProgramPractices offering longevity or bio-optimization programs with a hormonal focus

HormonesAnyone ready to move beyond serum tests and into full-spectrum hormone care

Make Hormones the Foundation of Your Longevity Model

This session gives you the tools to go beyond replacement and begin regulation. You’ll learn how to integrate hormone metabolite testing with toxin analysis and methylation mapping to create impactful, sustainable care programs for midlife adults, high performers, and perimenopausal patients alike.

You'll learn how to:

  • Use wet urine panels to assess hormone production, clearance, and receptor interference
  • Interpret estrogen detox and cortisol rhythm in the context of aging and stress
  • Build hormone-balancing programs that patients follow through on
  • Create high-retention care arcs around 3- or 6-month hormone cycles
Whether your patients are struggling with fatigue, brain fog, and weight gain or pushing for peak performance, this track helps you give them answers rooted in data.

Speaker Lineup

Dr. Craig Koniver MD

Dr. Craig Koniver MD

Learning Track Speaker
Dr. Tara Scott, MD

Dr. Tara Scott, MD, FACOG, FAAFM, ABOIM, CNMP

Learning Track Speaker
Dr. Carrie Jones

Dr. Carrie Jones ND, MPH, FABNE

Learning Track Speaker
Dr. Angela D Mazza

Dr. Angela D Mazza, DO, ABAARM, FAAMFM, ECNU

Learning Track Speaker
Longevity-Summit-Logo-Std

Interested in locking in your spot at Hormone Optimization: Elevating Lifespan and Peak Clinical Performance

Be sure to sign up for this learning track at registration when you arrive at The Vibrant Longevity Summit.